Publications

In Press

Andersen, M.K., MacMillan, H.A., Donini, A., Overgaard, J. (in press) Cold tolerance of Drosophila species is tightly linked to epithelial K+ transport capacity of the Malpighian tubules and rectal pads. The Journal of Experimental Biology. Early view.

2017

MacMillan H.A., Nørgård, M., MacLean H.J., Overgaard, J., Williams, C.J.A. (2017) A critical test of Drosophila anaesthetics: Isoflurane and sevoflurane are benign alternatives to cold and CO2. Journal of Insect Physiology. 101, 97-106.

MacMillan H.A., Yerushalmi, G., Jonusaite, S., Kelly, S.P., Donini, A. (2017) Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut. Scientific Reports. 7, 8807.

Jørgensen, L.B., Overgaard, J., MacMillan, H.A. (2017) Paralysis and heart failure precede ion balance disruption in heat-stressed European green crabs. Journal of Thermal Biology. 68, 186-194. 

O’Sullivan, J., MacMillan, H.A., Overgaard, J. (2017) Heat stress is associated with disruption of ion balance in the migratory locust. Journal of Thermal Biology. 68, 177-185.

Scarf I., Daniel A., MacMillan H.A., Katz N. (2017) The effect of fasting and body reserves on cold tolerance in two pit-building insect predators. Current Zoology. 63: 287-294.

Overgaard, J.O., MacMillan H.A. (2017) The integrative physiology of insect chill tolerance. Annual Review of Physiology. 79, 187-208.

Andersen, M. K., Folkersen, R., MacMillan, H.A., Overgaard, J. (2017) Cold acclimation improves chill tolerance in the migratory locust through preservation of ion balance and membrane potential. Journal of Experimental Biology. 220: 487-496.

2016

Yerushalmi, G.Y., Misyura, L., Donini, A., MacMillan, H.A. (2016) Chronic dietary salt stress mitigates hyperkalemia and facilitates chill coma recovery in Drosophila melanogasterJournal of Insect Physiology. 95: 89-97.

Ollson, T., Malmendal, A., MacMillan, H.A., Nyberg, N., Stærk, D., Overgaard, J. (2016) Hemolymph metabolites and osmolality are tightly linked to cold tolerance of Drosophila species: a comparative studyThe Journal of Experimental Biology. 219: 2504-2513.

MacMillan, H.A., Knee, J.M., Dennis, A.B., Udaka, H., Marshall, K.E., Merritt, T.J.S., Sinclair, B.J. (2016) Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. Scientific Reports. 6: 28999.

MacMillan, H.A., Schou, M.F., Kristensen, T.N., Overgaard, J. (2016). Preservation of potassium balance is strongly associated with insect cold tolerance in the field: A seasonal study of Drosophila subobscura. Biology Letters. 12: 20160123.

Scarf, I., Wexler, Y.,  MacMillan, H.A., Presman, S., Simson, E., Rosenstein, S. (2016) The negative effect of starvation and the positive effect of mild thermal stress on thermal tolerance of the red flour beetle. The Science of Nature. 103:20.

2015

MacMillan, H.A. Andersen, J.L., Davies, S.A., Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold toleranceScientific Reports. 5, 18607.

MacMillan, H.A. Baatrup, E., Overgaard, J. (2015) Concurrent effects of cold and hyperkalemia cause insect chilling injuryProceedings of the Royal Society B. 282, 20151483.

MacMillan, H.A., Andersen, J.L., Loeschcke, V., Overgaard, J. (2015) Sodium distribution predicts the chill tolerance of Drosophila melanogaster raised in different thermal conditions. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. 308, 823-831.

Andersen, J.L., MacMillan, H.A., Overgaard, J. (2015) Muscle membrane potential and insect chill comaThe Journal of Experimental Biology. 218, 2492-2495.

Andersen, J.L., MacMillan, H.A., Overgaard, J. (2015) Temperate Drosophila perserve cardiac function at low temperature. Journal of Insect Physiology. 77, 26-32.

Andersen J.L., Manenti, T., Sørensen, J.G., MacMillan, H.A., Loeschcke, V., & Overgaard, J.  (2015) How to assess Drosophila cold tolerance: chill coma temperature and lower lethal temperature are the best predictors of cold distribution limits. Functional Ecology. 29, 55-65.

Shamchuk A.L., MacMillan H.A.. (2015) Crossing boundaries and building bridges: integrative zoology. Canadian Journal of Zoology. 93: 677–678.

Coello Alvarado, L.E., MacMillan, H.A., Sinclair, B.J. (2015) Chill-tolerant Gryllus crickets maintain ion balance at low temperatures. Journal of Insect Physiology. 77, 15-25

MacMillan, H.A., Ferguson, L.V., Nicolai, A., Donini, A., Staples, J.F., Sinclair, B.J. (2015) Parallel ionoregulatory adjustments underlie phenotypic plasticity and evolution of Drosophila cold toleranceThe Journal of Experimental Biology. 218, 423-432.

2014

MacMillan, H.A., Findsen, A., Pedersen, T.H. & Overgaard, J. (2014) Cold-induced depolarization of insect muscle: Differing roles of extracellular K+ during acute and chronic chilling. The Journal of Experimental Biology. 217, 2930-2938.

MacMillan, H.A. & Hughson, B.N. (2014) A high-throughput method of hemolymph extraction from adult Drosophila without anaesthesia. Journal of Insect Physiology. 63, 27-31.

2013

Lake, S. L., MacMillan, H. A., Williams, C. M., & Sinclair, B. J. (2013). Static and dynamic approaches yield similar estimates of the thermal sensitivity of insect metabolism. Journal of Insect Physiology, 59(8), 761–766.

Sinclair, B. J., Ferguson, L. V., Salehipour-shirazi, G., & MacMillan, H. A. (2013). Cross-tolerance and cross-talk in the cold: Relating low temperatures to desiccation and immune stress in IinsectsIntegrative and Comparative Biology. 53(4), 546-556.

Sinclair, B. J., Stinziano, J., Williams, C. M., MacMillan, H. A., Marshall, K., & Storey, K. (2013). Real-time measurement of metabolic rate during freezing and thawing of the wood frog, Rana sylvatica: implications for overwinter energy use. The Journal of Experimental Biology216, 292–302.

2012

MacMillan, H. A., Williams, C. M., Staples, J. F., & Sinclair, B. J. (2012). Reestablishment of ion homeostasis during chill-coma recovery in the cricket Gryllus pennsylvanicus. Proceedings of the National Academy of Sciences of the United States of America, 109(50), 20750–20755.

MacMillan, H. A., Williams, C. M., Staples, J. F., & Sinclair, B. J. (2012). Metabolism and energy supply below the critical thermal minimum of a chill-susceptible insect. The Journal of Experimental Biology, 215(Pt 8), 1366–1372.

Williams, C. M., Marshall, K. E., MacMillan, H. A., Dzurisin, J. D. K., Hellmann, J. J., & Sinclair, B. J. (2012). Thermal variability increases the impact of autumnal warming and drives metabolic depression in an overwintering butterflyPLoS one7(3), e34470.

2011

Ransberry, V. E., MacMillan, H. A., & Sinclair, B. J. (2011). The relationship between chill-coma onset and recovery at the extremes of the thermal window of Drosophila melanogaster. Physiological and Biochemical Zoology, 84(6), 553–559.

MacMillan, H. A., & Sinclair, B. J. (2011). Mechanisms underlying insect chill-comaJournal of Insect Physiology57(1), 12–20.

MacMillan, H. A., & Sinclair, B. J. (2011). The role of the gut in insect chilling injury: cold-induced disruption of osmoregulation in the fall field cricket, Gryllus pennsylvanicusThe Journal of Experimental Biology214, 726–734.

Williams, C. M., Thomas, R. H., MacMillan, H. A., Marshall, K. E., & Sinclair, B. J. (2011). Triacylglyceride measurement in small quantities of homogenised insect tissue: comparisons and caveats. Journal of Insect Physiology, 57(12), 1602–13.

2010

 Bazinet, A. L., Marshall, K. E., MacMillan, H. A., Williams, C. M., & Sinclair, B. J. (2010). Rapid changes in desiccation resistance in Drosophila melanogaster are facilitated by changes in cuticular permeability. Journal of insect physiology, 56(12), 2006–12.

2009

MacMillan, H. A., Guglielmo, C. G., & Sinclair, B. J. (2009). Membrane remodeling and glucose in Drosophila melanogaster: a test of rapid cold-hardening and chilling tolerance hypotheses. Journal of Insect Physiology, 55(3), 243–9.

MacMillan, H. A., Walsh, J. P., & Sinclair, B. J. (2009). The effects of selection for cold tolerance on cross-tolerance to other environmental stressors in Drosophila melanogaster. Insect Science, 16(3), 263–276.

 

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